Preparation for What’s Nex

Dosing and administration for NEXVIAZYME

NEXVIAZYME: GIVEN AS A MONOTHERAPY*

The recommended dosage of NEXVIAZYME for patients weighing ≥30 kg is 20 mg/kg (of actual body weight) every 2 weeks, and for patients weighing <30 kg the recommended dosage is 40 mg/kg (of actual body weight) every 2 weeks.1 The initial recommended infusion rate is 1 mg/kg/hour. Gradually increase the infusion rate every 30 minutes if there are no signs of infusion-associated reactions (IARs).1

  • Prior to NEXVIAZYME administration, consider pretreating with antihistamines, antipyretics, and/or corticosteroids1
  • NEXVIAZYME must be reconstituted and diluted prior to use1

Not including premedication or pretreatment.

Projected intravenous infusion volume for NEXVIAZYME administration according to patient’s weight1

4-STEP PROCESS

PATIENT WEIGHT RANGE (kg)
TOTAL INFUSION VOLUME (mL)
Step 1
1 mg/kg/hour
Step 2
3 mg/kg/hour
Step 3
5 mg/kg/hour
Step 4
7 mg/kg/hour
INFUSION RATE (mL/hour)
APPROXIMATE TOTAL INFUSION DURATION

5 to 9.9

10 to 19.9

20 to 29.9

100

200

300

3

5

8

8

15

23

13

25

38

18

35

53

7 hours

30 to 34.9

25 to 49.9

50 to 59.9

60 to 99.9

100 to 219.9

120 to 140

200

250

300

500

600

700

10

13

15

25

30

35

30

38

45

75

90

105

50

63

75

125

150

175

70

88

105

175

210

245

4-5 hours

5-STEP PROCESS*

PATIENT WEIGHT RANGE (kg)
TOTAL INFUSION VOLUME (mL)
Step 1
1 mg/kg/ hour
Step 2
3 mg/kg/ hour
Step 3
5 mg/kg/ hour
Step 4
7 mg/kg/ hour
Step 5
10 mg/kg/ hour
INFUSION RATE (mL/hour)
APPROXIMATE TOTAL INFUSION DURATION

5 to 9.9

10 to 19.9

20 to 29.9

100

200

300

3

5

8

8

15

23

15

30

45

20

40

60

25

50

75

7 hours

40 mg/kg

20 mg/kg

Step 1 indicates the starting infusion rate. If there are no signs of IARs, gradually increase
the infusion rate every 30 minutes to the subsequent step.

*The 5-step process should be used only for subsequent infusions.

Step 1 indicates the starting infusion rate. If there are no signs of IARs, gradually increase the infusion rate every 30 minutes to the subsequent step.

The 5-step process should be used only for subsequent infusions.

See full Prescribing Information for administration instructions, including the recommended infusion rate schedule.

Dose modifications due to hypersensitivity reactions and/or IARs

Dose modifications with NEXVIAZYME may be necessary due to severe hypersensitivity reactions (including anaphylaxis) or a severe IAR. Please consult the full Prescribing Information for instructions on appropriate dose modifications before beginning administration.1

Switching to NEXVIAZYME can be a seamless process

For patients who are switching to NEXVIAZYME, the label does not require a washout period between the final alglucosidase alfa dose and the first NEXVIAZYME dose.1,2 Patients may also be able to keep their same dosing schedule and their same infusion center.1

NEXVIAZYME Dosing Guide

Important information for the dosing and administration of NEXVIAZYME.

Physician Order Form

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